Lee,
The frames can be made with a single piece. Intuitively, it seems that a frame from chine to chine would be stronger...then the prop shaft hole blows through a frame and the engine clearance wipes out the next one.
Making the frames would be more economical using a narrower boards and cutting the joint over the keel might be easier than all the symmetric ripping cuts needed to make the frame profiles.
Fasteners in the aft frames can REALLY get in the way later. (I removed the middle third of several screws

) Take a look at the prop shaft/shaft log location. Chances are there are 2#10 screws called for between frame and keel, screws between keel layers, screws between frame and floor timber. Make yourself a no-screw-zone to save yourself the effort of cutting them out later.
Tom